Chinese scientists have developed a multifunctional black bioactive ceramic material

Bioceramic materials have a long history of being used to repair human hard tissues, from biologically inert materials (such as alumina and zirconia, etc.) to biological materials that are both biologically active and degradable (such as phosphate and silicate bioceramics, silicon Based bio-glass, etc.), its physiological function is no longer a simple tissue filling substitute, but a tissue engineering material that can induce tissue regeneration, regulate cell growth and functional differentiation. More and more evidences show that specific bioactive ceramic materials have the effect of promoting the specific cell regeneration activity of soft/hard tissues, and are widely used in the repair of tissue defects in bones, teeth and skin. However, there are many special tissue damages in clinical practice, such as tissue defects after surgical resection of bone tumors or skin cancer tissues. It is necessary to remove the remaining tumor cells before repairing the tissue defects to avoid tumor recurrence. In order to achieve the dual functions of tumor treatment and tissue regeneration, the preliminary research has prepared photothermal functionalized bioactive ceramic materials by compounding bioactive ceramics with photothermal reagents with tumor treatment functions. Although this is an effective strategy, the long-term safety of photothermal nanoreagents in vivo remains to be investigated. Therefore, how to realize the integration of tissue regeneration and tumor treatment functions of the bioactive ceramic material itself without introducing foreign additives is particularly important.

04-29

2024

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